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About Elizabeth Jaworski Ph.D.
Elizabeth Jaworski, Ph.D. is the CEO and Co-Owner of ClickSeq Technologies, a dedicated researcher in viral recombination and a Biodesign Founder at TMC Innovation.
She is a multidisciplinary expert in next generation sequencing, virology, and the dynamic intricacies of launching a biomedical startup.
Elizabeth completed her Ph.D. studies in the Department of Biochemistry and Molecular Biology (BMB) at the University of Texas Medical Branch (UTMB). She began studying the role of RNA splicing and RNA metabolism in skeletal muscle development and later transitioned into the field of RNA virus recombination. During her time in the research lab investigating the formation and emergence of defective RNA genomes of RNA viruses, she developed a new form of sequencing technology that improved the efficiency and accuracy of standard sequencing methods.
The discovery of this sequencing technology and the other R&D efforts of ClickSeq would later lead to the creation of her company, ClickSeq Technologies - a simple method for synthesizing Next-Generation Sequencing libraries.
To secure funding and successfully launch ClickSeq Technologies, Elizabeth participated in various pitch competitions and entrepreneurial programs like BioVentures - a 10-week immersive program that supports participants in turning their life science ideas into a successful business.
In pitch competitions, she won second place in the regional T1-T4 in 3 Minutes Challenge at the Science of Team Science Conference. She went on to successfully secure funding toward the development of ClickSeq’s technologies. After participating in The National Science Foundation’s Innovation Corps (NSF I-Corps), ClickSeq became a fully operating company that has begun to acquire clients and gain positive feedback.
Embarking on her next innovative breakthrough, Elizabeth is currently a Founder at TMC Biodesign - a year-long innovation program that supports ambitious entrepreneurs like Dr. Jaworski in expediting the process of bringing scientific innovations to market.
In her spare time, Elizabeth enjoys mentoring the next generation of brilliant minds hoping to fill gaps in the biomedical industry and improve people's health and well-being all over the world. She is also a Licensed Private Pilot and continues to challenge herself to push the boundaries of her comfort, develop her mental acuity and resilience, and nurture the evolution of her personal growth.
Awards
Rob Braiser Award for Best Mentor (Bench Mentors)
Best Team Science Award (Bench Mentors)
T1-T4 in 3 Minutes Challenge (SciTS Conf), 2nd place
T1-T4 in 3 Minutes Challenge (UTMB), 1st place
Mission
Push the envelope to create new pathways for life science innovation.
Core Values
Value independent thinking.
Focus, dig deep, and filter out the noise.
Find excitement in challenging situations.
Remember perfection doesn’t lead to innovation.
Act on instinct, direct with knowledge, grow with intellect.
Connect with Elizabeth on LinkedIn
PATENT AND PUBLICATIONS
PATENT
Poly(A)-ClickSeq: Click Chemistry for Next Generation 3’ End Sequencing without RNA Enrichment or Fragmentation. Inventors: Routh, A., Wagner, E., Jaworski, E., Ji, P.; Patent: US 16/282,159; Filed: February 22 nd , 2019
PUBLICATION
Langsjoen, R.M., Muruato, A.E., Kunkel, S.R., Jaworski, E., Routh, A. (2020) Differential Alphavirus Defective RNA Diversity between Intracellular and Extracellular Compartments Is Driven by Subgenomic Recombination Events. mBio July/August 2020, doi: 10.1128/mBio.00731 20
PUBLICATION
Kautz, T.F, Jaworski, E.A., Routh, A., Forrester, N.L. (2020) A Low Fidelity Virus Shows Increased Recombination during the Removal of an Alphavirus Reporter Gene. Viruses, June 2020, doi.org/10.3390/v12060660
PUBLICATION
Elrod, N.*, Jaworski E.A.*, Ji,P., Wagner, E., Routh, A. (2019) Development of Poly(A)- ClickSeq as a tool enabling simultaneous genome-wide poly(A)-site identification and differential expression analysis. Methods, Jan. 2019, doi: 10.1016/j.ymeth.2019.01.002 *Co-first authors
PUBLICATION
Routh, A., Ji, P., Jaworski, E.A., Xia, Z., Li, W., Wagner, E. (2017) Poly(A)-ClickSeq: click- chemistry for next-generation 3’-end sequencing without RNA enrichment or fragmentation. Nucleic Acids Research, Apr. 2017, doi: 10.1093/nar/gkx286
PUBLICATION
Reyes Ruiz, J.M., Osuna-Ramos, J.F., Baustista-Carbajal, P., Jaworski, E., Soto-Acosta, R.,Cervantes-Salazar, M., Angel-Ambrocio, A.H., Castillo- Munguía, J.P., Chávez-Munguía, B., Nova-Ocampo, M., Routh, A.L., del Ángela, R.M., Salas-Benito, J.S. (2019) Mosquito cells persistently infected with dengue virus produce viral particles with host-dependent replication. Virology, Feb. 2019, doi: 10.1016/j.virol.2019.02.018
PUBLICATION
Jaworski E.A., Routh, A. (2017) Parallel ClickSeq and Nanopore Sequencing elucidates the rapid evolution of Defective-Interfering RNAs in Flock House virus. PLoS Pathogens, May 2017, 13(5):e1006365
PHD DISSERTATION
Jaworski, E., The broken genome: Merging cutting edge technologies for a molecular understanding of the lock House virus defective interfering particle. (Aug. 2018)
BOOK CHAPTER
Jaworski E.A., Routh, A. (2018) ClickSeq: Replacing fragmentation and enzymatic ligation with click-chemistry to prevent sequence chimeras. Methods in Molecular Biology Dec. 2017, 1712:71-85.